Unsaturated fatty acidtriacylglycerolspolymorphismbinary mixturesRecent studies on molecular structures and interactions of unsaturated fatty acids, diacylglycerols and triacylglycerols have been reviewed. An emphasis was paid to elucidate thermodynamic and kinetic behavior of polymorphic transformation, molecular-...
7 A unique type of unsaturated oil is rapeseed oil (Canola), which is mainly monounsaturated fat but also has omega-3 fatty acid and α-linolenic acid (ALA) components. The Lyon Heart Study used rapeseed oil with a Mediterranean diet in a secondary prevention study and found a reduction in...
Unsaturated fatty acids (UFAs), with the distinct advantages of good biocompatibility and innate tumor-targeting effect, have been widely investigated for the rational design of chemotherapy agent-unsaturated fatty acid (CA-UFA) prodrugs in cancer therapy. Among them, several CA-UFA prodrugs ha...
Further studies are needed to clarify the molecular mechanisms of how omega-6 and omega-3 HUFAs modulate male steroid hormone production. HUFAs are believed to be synthesized from essential fatty acids (i.e., linoleic acid and α-linolenic acid) in the liver and transported to other ...
Although unsaturated fatty acids have long been known to accompany saturated fatty acids in most lipids, qualitative and quantitative determination of fatty acid patterns only became possible with the advent of modern analytical methods. Present day knowledge of the chemical structure, physical properties...
(Fig.S8C). From the fragmentation pattern of the peroxidized form, dihomo-γ-linolenic acid showed a similar fragmentation pattern as that of the C18:3 fatty acids described above (Fig.S8A,C; the fragment spectra of cyclic peroxide are shown). In contrast, sciadonic acid yielded the same...
Structure of fatty acids and scheme for fatty acid oxidation. (A) Structure of polyunsaturated and saturated fatty acids. Scheme for air oxidation of fatty acid. (B) Fatty acids were autoxidized for 2 days in the presence of 80% N2 and 20% O2. Ox, oxidized. ...
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. Human fatty acid synthase (hFAS) thioesterase domain (TE) is an attractive drug target to treat obesity and cancer. On the basis of the recently published ... C Feng,Q ...
1 The abbreviations used are: ALS, amyotrophic lateral sclerosis; FALS, familial amyotrophic lateral sclerosis; SOD1, superoxide dismutase 1; FA, fatty acid; AA, arachidonic acid; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium. ...
On the other hand, in the intestinal lumen, enhanced postprandial lysophospholipid absorption can suppress hepatic fatty acid oxidation, lead to increased VLDL synthesis and tissue lipid deposition, and improve diet-induced hyperlipidemia50. The negative correlation of cholesterol with atrial dilatation and...