2023年8月14日,俄亥俄州立大学、俄勒冈健康与科学大学、维克森林大学医学院、加州大学旧金山分校的研究人员在国际顶尖医学期刊Nature Medicine上发表了题为:GDNF gene therapy for alcohol use disorder in male non-human primates 的研究论文【2】。 这项在非人灵长类动物恒河猴中的研究证明,使用腺相关病毒2型(AAV2...
NSCs组,GDNF/NSCs组显著高于NS组(P<0.05);GDNF/NSCs组高于NSCs组(P<0.05).结论 GDNF/NSCs移植治疗脑中风的机制可能与促进GAP-43表达有关.%Objective To study the effects of grafting neural stem cells( NSCs) modified by glial cell line-derived neural factor( GDNF) gene ( GDNF/NSCs) on the ...
研究人员Grant 补充说道:“接受这种基因治疗的猴子开始永久提高多巴胺,并且大大减少了饮酒量。这种治疗手段确实通过手术永久性地改变了大脑,因此仅限于那些患有最严重的酒精使用障碍的人。” The monkeys that were treated with this gene permanently started overexpressing dopamine and they decreased their drinking su...
关键词GDNF;BMSCs;缺氧复氧;神经细胞;共培养中图分类号R741.05文献标识码A文章编号1000—2669(2011)5—0552—04EXPERIMENTALRESEARCHoNCo—CULTIVATIoNoFBoNEMARRoWMESENCHYMALSTEMCELLSMoDIF皿DBYGDNFGENEANDNEURoNSSUBJECTEDTOANoXIA—REoXYGENATIoNXiongHuailin,etalDepartmentofHumanAnatomy,LuzhouMedicalCollegeAbstractObjective:...
基因序列:NCBI_Gene:25453 蛋白序列: UniprotKB:A7UGI9 UniprotKB:A7UGJ1 UniprotKB:F8WFL7 UniprotKB:Q07731 大鼠Rat Gdnf 靶点分子功能(预测) Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to...
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11 Pineda JR, Rubio N, Akerud P, et al.Neuroprotection by GDNF-secreting stem cells in a Huntington′s disease model:optical neuroimage tracking of brain-grafted cells[J].Gene Ther, 2007, 14(2):118-128. 12 Ledda F, Paratcha G, Sandoval-Guzmán T, et al.GDNF and GFRα1 promote ...
GDNF基因修饰的骨髓基质干细胞移植治疗大鼠脑出血
[ IDENTIFICATION ] Figure . Gene Sequencing (extract) [ IMPORTANT NOTE ] The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures. ATF1;ATF2;HFB1;胶质细胞系来源神经营养因子(GDNF)重;公司...
复旦大学硕士学位论文神经营养因子GDNF在神经干细胞发育研究中的作用姓名:***请学位级别:硕士专业:遗传学指导教师:**元20020610神经营养因子GDNF在神经干细胞发育研究中的作用.摘要胶质细胞源性神经营养因子(GDNF)是一种重要的维持神经元存活的神经蛋白质分子,对于多巴胺神经元和运动神经元而言,它的作用活性强于其他所有...