Her COVID-19 nasopharyngeal swab test was negative at the time of current presentation. Spinal fluid analysis showed 0 WBC, 0 RBC, and protein of 20 mg/dL. Her B12 level was normal at 499 pg/mL. Ganglioside antibody panel was positive for multiple antibodies (see table). Patient deferred...
Therefore, we investigated the presence of six common antibodies with a commercially available test panel for GA1, GM1, GM2, GD1a, GD1b and GQ1b in a large group of clinically well-characterized ALS patients and compared them to a collective of 200 healthy blood donors.IgG and IgM ...
Monocytes were purified from human peripheral blood upon centrifugation over NycoPrep™1.068 (Axis-Shield, Oslo, Norway) as previously described (11). Incidental non-monocytes were removed by magnetic depletion using a mixture of biotin-conjugated monoclonal antibodies (mAbs) and magnetic microbeads ...
using anti-GM2 antibodies, may lead to new PDAC therapies targeting GM2. Downregulation of NEU3, a plasma membrane-associated sialidase that modulates ganglioside content by removing sialic acid, is known to contribute to increases in GM2 expression35. As shown in this study, NEU3 expression ...
A protein produced in the blood or tissues in response to the presence of a specific foreign antigen. Antibodies provide immunity against certain microorganisms and toxins by binding with them and often by deactivating them. Also calledimmunoglobulin. ...
involved in cell growth regulation and in cell-cell and cell-matrix adhesion. Moreover, gangliosides are expressed on the cell surface and thereby are accessible for antibodies or other ganglioside-binding molecules to induce cell death, inhibit cell growth and/or inhibit formation of tumour ...
Besides producing antibodies, tumor-infiltrating B cells can present antigens to T cells and secrete a variety of cytokines [135]. However, tumor-infiltrating B cells are also able to promote angiogenesis or secrete immunoregulatory cytokines, including TGFβ and IL-10, that suppress the anti-...
In order to exclude the species specific natural antibodies that might react to M12 cells in the IA assay, the immunized murine sera were pre-absorbed by human red blood cells at 4° C. overnight. An IA score of 4+ was obtained at 1:10 dilution of the absorbed sera. Control sera gave...
A case-control study was performed in a tertiary care teaching hospital for the estimation of anti-ganglioside antibodies in GBS patients and their controls. Blood samples were collected from 59 GBS cases, 58 neurological controls (NC) and 60 non-neurological control (NNC) patients for automatic ...
Blood samples were collected from 59 GBS cases, 58 neurological controls (NC) and 60 non-neurological control (NNC) patients for automatic estimation of IgG and IgM antibodies to seven gangliosides using EUROLineScan software. Antibodies of IgG class for GM1 were highly significant in GBS (p =...