This approach provides another option for management of newborns with documented coagulation factor deficiency. The subsequent development of an inhibitor directed against FVIII is believed to be related to exposure to exogenous FVIII in the presence of an inversion mutation and not to the intrauterine ...
4.hemophilia caused by a congenital deficiency of factor VIII; occurs almost exclusively in men.由于先天缺乏凝血银子VIII而引起的血友病;通常出现在男性。 5.Vascular loop compression of the eight cranial nerve was found in all patients.术中均见有血管袢压迫第VIII颅神经。 6.A Text Analysis of Edwar...
Type 1 von Willebrand disease (VWD) is characterized by a partial quantitative deficiency of von Willebrand factor (VWF). Few VWF gene mutations have been ... SL Haberichter,M Balistreri,P Christopherson,... - 《Blood》 被引量: 236发表: 2006年 A new von Willebrand factor (vWF) defect in...
Combined FV and FVIII deficiency achieved through the use of fresh frozen plasma, and that of FVIII by desmopressin or specific FVIII concentrates, plasma-derived or recombinant FVIII ... M Spreafico,F Peyvandi - 《Haemophilia》 被引量: 125发表: 2008年 Cumulative inhibitor incidence in previously...
download full-size image previous article in issue next article in issue introduction hemophilia a is an inherited bleeding disorder, resulting from a deficiency in blood coagulation factor viii (fviii). it predominantly affects males, with an incidence of 1 to 2 individuals per 10 000; however,...
喜欢 0 阅读量: 193 作者: Bray,GL,沈琦 展开 摘要: 八十年代中期到后期发展了新一代的血浆FⅧ浓制剂,明显地提高了FⅧ纯度和减少了病毒感染的危险性.本文着重讨论这些新制剂治疗甲型血友病的临床问题和用重组DNA法生产FⅧ制剂的目前状况. 展开 关键词: 血浆;血友病;FVIII 年份: 1991 收藏...
Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice. Hemophilia A is caused by a deficiency in coagulation factor VIII (FVIII) and predisposes to spontaneous bleeding that can be life-threatening ...
SubQ-8 is Octapharma’s developmental rFVIII product for subcutaneous administration, currently in the preclinical stage. About Haemophilia A Haemophilia A is an X-linked hereditary disorder caused by FVIII deficiency which, if left untreated, leads to haemorrhages in muscles and joints and consequentl...
Hemophilia A is a dominant hemophilic disorder, affecting 1 in 5000 males, and is caused by a deficiency in coagulation factor VIII (FVIII)1,2. Patients with severe cases of hemophilia A suffer from frequent spontaneous bleeding events in various organs, including the joints and muscles, that ...
Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency Blood, 101 (10) (2003), pp. 3933-3939 View PDFView articleView in ScopusGoogle Scholar [30] C.J. van Schooten, S. Shahbazi, E. Groot, B.D. Oortwijn, H.M. van den Berg, C...