SensitivedetectionFGFR3mutationsbladdercancerurinesedimentspeptidenucleicacid-mediatedreal-timePCRclampingMakitoMiyakeKokichiSuganoKiyotakaKawashimaHirokiIchikawaKaoruHirabayashiTetsuroKodamaHiroyukiFujimotoTadaoKakizoeYaeKanaiKiyohideFujimotoYoshihikoHiraoOncogeneResearchUnit/CancerPreventionUnit,TochigiCancerCenterResearchInstitute,4...
Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders. Eur J Hum Genet 2002; 10:819-24.van Rhijn, B.W., van Tilborg, A.A., Lurkin, I., Bonaventure, J., de Vries, A., Thiery, J.P., van der Kwast, T...
[14]LIUX,ZHANGW,GENGD,etal.Clinicalsignificanceoffibroblast growthfactorreceptor 3mutationsinbladdercancer:asystematicre view and meta analysis[J].Geneticsand MolecularResearch, 2014,13(1):1109 1120. [15]ZHAOX,NINGQ,SUNX,etal.PokemonreducesBcl 2expression throughNF kappaBp65:A possiblemechanism of...
fgfr3、ef-1、p21、和rb蛋白在膀胱移行细胞肿瘤组织中的表达及意义.pdf,中文摘要 表达及意义 摘要 目的:膀胱肿瘤是泌尿系统中常见的恶性肿瘤,而膀胱肿瘤中绝大多 transitionalcell 数均为恶性肿瘤。膀胱移行细胞癌(bladder carcinoma, BTCC)对人类的身体危害严重,目前
FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. FGFR3 mutations are associated with low-grade tumors and a favorable prognosis. Tp53 alterations are associated with advanced tumors and, possibly, with a poor prognosis...
It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5)....
OUSATI A Z, MEHRSAI A R, POURMAND M R, et al. High resolution melting analysis for rapid detection of PIK3CA gene mutations in bladder cancer: a mutated target for cancer therapy[J]. Urol J, 2018, 15(1): 26-31. JUANPERE ...
The fusion of the fibroblast growth factor receptor gene 3 (FGFR3) with the transforming acidic coiled-coil containing gene (TACC3) has been described in glioblastoma multiforme, bladder urothelial carcinoma, and non-small cell lung cancer (Wu et al., 2013). While FGFR mutations have been ...
Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443). Technical Data DNA Change c.1200insCC AA Change p.SP400fs...
Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443). Technical Data DNA Change: c.746C>G AA Change p.S249C ...