et al. The FGFR3 Mutation is Related to Favorable pT1 Bladder Cancer. J Urol 187, 310-314 (2012).van Rhijn BW, van der Kwast TH, Liu L, Fleshner NE, Bostrom PJ, Vis AN, et al. The FGFR3 mutation is related to favorable pT1 bladder cancer. J Urol 2012;187:310-4....
YOKOTA T, SERIZAWA M, HOSOKAWA A, et al. PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue[J]. BMC Ca...
研究背景:膀胱尿路上皮癌(urothelial bladder cancer,UBC)是全球第10大常见高发恶性肿瘤.约75%以上的患者初次诊断时为非肌层浸润性的膀胱癌(non-muscle-invasive bladder cancer,NMIBC),其中约20%为T1期的膀胱癌(T1 UBC),即肿瘤侵犯固有层但尚未侵及固有肌层.与其它NMIBC相比,T1 UBC具有与侵袭性肿瘤相似的生物学...
FGFR3, TERT, ТР53 mutations and the FGFR3 gene expression in bladder cancer as prognostic markers was demonstratedfor the prognostic classifier with the independent variables: mutation in FGFR3 and/or TERT; mutation TP53; overexpression of the FGFR3 gene... DS Mikhaylenko,SA Sergienko,EB Ku...
In the COSMIC database, FGFR3 mutation has been found in 2 out of 120 cervical squamous cell carcinoma specimens. In the cervical squamous cell carcinoma and endocervical adenocarcinoma TCGA dataset, putative high-level amplification of FGFR3 was reported in < 1% (1/212) of samples analyzed (...
Overexpression of fibroblast growth factor receptor 3 ( FGFR3 ) has been shown to drive oncogenesis in a subset of patients with multiple myeloma. However, epithelial cancers — such as bladder cancer — also exhibit deregulation and mutation of FGFR3, but whether this contributes to tumorigenesis...
A point mutation in FGFR3 can lead to achondroplasia. Search Lungs as well as fissure form is owned by age inside Posted onOctober 5, 2024 Reply Nevertheless, concept of normal circulation values for specific age groups is challenging considering that the results revealed large difference and stan...
The fibroblast growth factor receptor (FGFR) family members mediate a number of important cellular processes, and are mutated or overexpressed in several forms of human cancer. Mutation of Lys650-->Glu in the activation loop of the FGFR3 kinase domain causes the lethal human skeletal disorder tha...
Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443). Technical Data DNA Change: c.746C>G AA Change p.S249C ...
Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443). Technical Data DNA Change c.1200insCC AA Change p.SP400fs...