they are either symptoms of prodromal Alzheimer’s disease (i.e., biased by reverse causation) or spurious associations due to confounding and/or selection bias. This conclusion is corroborated by the findings observed in the PheWAS, which are similar to those in observational studies (such as ...
For future versions of the database, we are planning to integrate disease symptoms and drug side effects data, which will allow investigation into different disease similarity and drug repositioning approaches. Regarding drug indications, previous studies (e.g., RepoDB66) include instances of failed ...
The prophylactic, anti-Alzheimer effect of the ARBs and beta blockers suggest that they play a role at the inception steps in the development of degenerative symptoms. Consequently, understanding of the pathways opposed by these agents has a substantial value since these pathways are likely to be...
Also, similar symptoms can appear in various diseases, which adds to the complexity of disease classification. To solve this problem, the most realist option is to gradually enrich the diversity of the dataset [16], using more data to make it robust to symptom variation. Many machine learning...
(PD) is related to many non-motor symptoms that complement to overall disability. Conventionally, it is characterized by motor symptoms such asbradykinesia, tremor, and altered gait, hence,dopaminergic neuronsinsubstantia nigramight be lost. Nevertheless, there are some recommended drugs for the ...
Thus, the early prediction of high-risk CAC allows individuals to prevent coronary heart disease (CHD) from progressing to extreme symptoms and illnesses. The process of identifying and using various predictors to predict CAC has received increasing attention, which has helped clinicians and patients ...
The extensive annotations, including details on demographics, medical history, symptoms, and movement steps, provide a comprehensive database to ML techniques and encourage further investigations into phenotypical biomarkers related to movement disorders....
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor impairments such as tremor, bradykinesia, dyskinesia, and gait abnormalities. Current protocols assess PD symptoms during clinic visits and can be subjective. Patient diarie
689 diseases of men or women were categorised as acute, chronic, infectious, injuries, or symptoms of unknown cause (separate plots), and grouped by the number of cases (horizontal axes). We considered: whether associations were statistically significant at the 0.05 level after a Bonferroni multi...
The detection of this virus may fall back on these yardsticks: “clinical symptoms,”“epidemiological history,” and “positive X-ray images.” The clinical physiognomies of this virus's include “respiratory symptoms,”“fever,”“cough,” and “pneumonia” [[12], [13], [14], [15]]. ...