14.Riches DW, et al. ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis. Am J Pathol. 2015 Apr;185(4):909-12. 15.Flynn, R., et al., Targeted Rho-associated kinase 2 inhibition suppresses murine and...
17.Zanin-Zhorov and Blazar. ROCK2, a Critical Regulator of Immune Modulation and Fibrosis Has Emerged as a Therapeutic Target in Chronic Graft-versus-Host Disease. Clin Immunol. 2021 September ; 230: 108823 18.Flynn R, Paz K, Du ...
CSF-1-activated macrophages induce inflammatory response and tissue damage, accelerate abnormal tissue repair and fibrosis, and lead to cGVHD. Recent studies have shown that inhibition of CSF1-R can reduce the expansion
Chronic graft-versus-host disease (cGvHD), characterized by inflammation and fibrosis of multiple target organs, considerably contributes to the morbidity and mortality even years after allo-HSCT. Diagnosis of cGvHD is based on clinical features and histology of biopsies. Here, we report the ...
in a press release. "Axatilimab is the first investigational chronic GVHD treatment to target inflammation and fibrosis through the inhibition of disease associated macrophages, and the AGAVE-201 data demonstrates the potentially pronounced impact this mechanism, alone or in combination with standard of...
“In terms of organ-specific response, complete remission [CR] was seen across all organs involved,” Wolff said. Responses with axatilimab at 0.3 mg/kg every 2 weeks were also seen in fibrosis-dominated organs. CRs were observed in the following organs: lower gastrointestinal (GI; n = 9...
Objective To illustrate the potential effects and mechanism of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) on fibrosis in sclerodermatous chronic graft-versus-host-disease (cGVHD) models after allogeneic hematopoietic stem cell transplantation. Methods We first observed the therapeut...
“In terms of organ-specific response, complete remission [CR] was seen across all organs involved,” Wolff said. Responses with axatilimab at 0.3 mg/kg every 2 weeks were also seen in fibrosis-dominated organs. CRs were observed in the following organs: lower gastrointestinal (GI; n = 9...
and the common characteristic pathological changes are chronic tissue repair and fibrosis. In this process, macrophage activation dependent on colony stimulating factor (CSF-1) promotes inflammatory response and tissue damage, and accelerates abnormal tissue repair and fibrosis, leading to the manifestations...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative, but is associated with significant morbidity and mortality. Chronic graft-versus-host disease (cGvHD), characterized by inflammation and fibrosis of multiple target organs, c