Cystic fibrosis (CF), is a life-threatening autosomal recessive genetic disorder that originates from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene1. The most prevalent mutation is the deletion of a phenylalanine residue at position 508 (F508del) within the first n...
The conducting airways also have a role of preventing any noxious matter from reaching the alveolar gas exchange site. To accomplish this role, the epithelial cells lining the airways are protected from the inspired air by a thin (~10 μm) liquid layer called the airway surface liquid (ASL) ...